Monitor Intently (1)belzutifan will reduce the level or outcome of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism.Watch Carefully (one)mitotane decreases levels of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Mitotane is a strong inducer of cytochrome P-4503A4; keep track of when coadmin